The research centres on control and prevention of diseases in resource-poor areas, however, methodologically the activities span from the molecular and immunological, through clinical trials and cohort studies to health systems and anthropological investigations. The latter have agreed to fund an exciting new R&D programme collaborating with OxfordUniversity “ A circumsporozoite protein vaccine against malaria using the adenovirus Ch63 vector: preclinical and Phase I safety and immunogenicity studies”. As malaria is being controlled in Gambia the needs increased for a National malaria surveillance system, performed in collaboration with CIAM, a research NGO there, and with the Gambian Ministry of Health. This started in Feb 2008 and is Irish Aid/HRB funded in a catalytic way that will be sustainable. Migrants and asylum seekers moving into Ireland is a recent phenomenon, however in 2006 census 17% of people living here were not born in Ireland. A major research effort has been launched to understand how the Irish health system has responded to this, commencing in April 2009 and ongoing.
Cavenaugh JS, Awi D, Mendy M, Hill AV, Whittle H, McConkey SJ. Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection. PLoS One. 2011 Feb 15;6(2):e14626.
Jallow S, Alabi A, Sarge-Njie R, Peterson K, Whittle H, Corrah T, Jaye A, Cotten M, Vanham G, McConkey SJ, Rowland-Jones S, Janssens W. Virological response to highly active antiretroviral therapy in patients infected with human immunodeficiency virus type 2 (HIV-2) and in patients dually infected with HIV-1 and HIV-2 in the Gambia and emergence of drug-resistant variants. J Clin Microbiol. 2009 Jul;47(7):2200-8. Epub 2009 May 6
Mendy ME, McConkey SJ, Sande van der MA, Crozier S, Kaye S, Jeffries D, Hall AJ, Whittle HC. Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia. Virol J. 2008 Apr 16;5:49. PubMed PMID: 18416832;
Hammond AS, McConkey SJ, Hill PC, Crozier S, Klein MR, Adegbola RA, Rowland-Jones S, Brookes RH, Whittle H, Jaye A. Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression. J Infect Dis. 2008 Jan 15;197(2):295-9.
van der Sande MA, Waight PA, Mendy M, Zaman S, Kaye S, Sam O, Kahn A, Jeffries D, Akum AA, Hall AJ, Bah E, McConkey SJ, Hainaut P, Whittle HC. Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. PLoS One. 2007 Aug 15;2(1):e753. PubMed PMID: 17710152; PubMed Central PMCID: PMC1940311.
van der Sande MA, Kaye S, Miles DJ, Waight P, Jeffries DJ, Ojuola OO, Palmero M, Pinder M, Ismaili J, Flanagan KL, Aveika AA, Zaman A, Rowland-Jones S, McConkey SJ, Whittle HC, Marchant A. Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban West-African birth cohort. PLoS One. 2007 Jun 6;2(6):e492